Which among the following neurotransmitters is decreased in depression and increased in mania?

Answer:

Depression and mania can both be difficult to understand. To make things a little easier to identify, we thought we’d take a look at dopamine. Dopamine can increase in the brain during manic phases of bipolar disorder or when using drugs or alcohol in an attempt to treat the hyperactive symptoms of depression. The dopamine receptor called D 2 is decreased in people with depression and increased in mania. That is why a class of drugs called [insert drug name] that block this neurotransmitter are used to treat both depression and mania in bipolar patients.”

If you’re confused about neurotransmitters and the role they play in mood disorders, you’re not alone. Perhaps one of the most confusing issues is whether or not neurotransmitter levels are decreased or increased in depression and if they are affected in mania. It’s also important to understand that there are many neurotransmitters functioning in the brain at any given time, so some people will be low or high on one and normal on others.

Some neurotransmitters are decreased in depression, for instance the dopamine and serotonin are decreased by 50% compared to normal mood. These two chemicals play a major role in regulating mood. Another neurotransmitter that is decreased in depression is norepinephrine which causes fatigue and affects sleep patterns.

Dear NursingStudent, Great question! Your best answer is that the correct neurotransmitter for your example is dopamine. Dopamine has been implicated in depression as well as mania, but the most solid evidence is related to its role in reward-seeking behavior. Both depressed and manic individuals exhibit anhedoniaand decreased motivation, key components of an “unrewarding” experience. Recently, there have been studies suggesting that increased dopamine activity may help restore this reward response in depression.

Scientists once thought that depression and mania were two separate disorders, but with advancements in medical technology in the past decade or so, we now know that the two disorders are closely linked. In fact, many people who suffer from mania also tend to experienced major depressive episodes throughout their lives.

There are many imbalances that are associated with depression. One of the major ones is a decrease in neurotransmitters such as serotonin, dopamine, and norepinephrine. These neurotransmitters are involved in mood regulation and affect your wellbeing. They may also be involved in memory, appetite, temper and sleep patterns.

The neurotransmitter that determines whether you feel up or down is dopamine. If your serotonin level goes down, you’re going to be more nervous, anxious and generally depressed. Serotonin is found in almost all the cells of the body, but most of it is found in cells in the brain.

Depression is one severe mental illness and has been treated with different psychotherapies and medications. The major problem in this treatment is recurrence of depression after remission. However, the mechanism underlying depression is unclear. Clinical trials with novel compounds to treat depressive disorder have yielded a new strategy for treating major depression by increasing the function of NMDA receptors that adress some neurotransmitters including glutamate or serotonin .

Everyone seems to be talking about neurotransmitters lately, so let’s find out what they are, how they work, and why they might be involved in depression. In this article you will learn about the possibility that abnormally decreased levels of one neurotransmitter, serotonin (5-HT), may be part of what causes depression (and possibly also obesity).

Serotonin, Dopamine, GABA, Noradrenaline

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